Contactin-associated protein-like 4 (CNTNAP4)

Contactin-associated protein-like 4 (CNTNAP4) is a transmembrane protein of the neurexin superfamily that functions primarily as a cell adhesion molecule and receptor in the vertebrate nervous system[2][3][7]. It is characterized by multiple functional domains, including epidermal growth factor (EGF) repeats, laminin G domains, and other cell interaction motifs[2][3]. CNTNAP4 is involved in regulating synaptic development and neurotransmitter release, particularly affecting inhibitory (GABAergic) and dopaminergic signaling, and is implicated in the proper formation and function of neural circuits[1][3][7]. Pathogenic variations or dysregulation of this protein are associated with autism spectrum disorder, epilepsy, some psychiatric illnesses, and potentially bone developmental syndromes due to its interaction with ligands such as Neural EGFL-like 1 (Nell-1)[1][3][6]. As a synaptic cell adhesion molecule and emerging receptor, it represents a target of interest for neuropsychiatric and developmental research.

Other names

CASPR4KIAA1763cell recognition molecule Caspr4contactin associated protein family member 4