Coordinator of PRMT5 and differentiation stimulator (COPRS)

COPRS (Coordinator of PRMT5 and differentiation stimulator) is a nuclear histone-binding adaptor protein essential for the recruitment and substrate specificity of PRMT5, a protein arginine methyltransferase. COPRS binds specifically to the N-terminus of histone H4, promoting PRMT5-mediated methylation of H4 arginine 3 (H4R3) and is implicated in the repression of cell cycle genes such as cyclin E1 (CCNE1). COPRS is expressed in most tissues, localizes to the nucleus, and functions in chromatin remodeling, cell differentiation (especially muscle cell differentiation), and cell cycle exit. It has been associated with chromosomal deletion syndromes and studied in cancer proliferation pathways, but is not currently a direct drug target. COPRS appears to function as a bridging adaptor, linking PRMT5 to chromatin at specific loci, thereby regulating gene expression and cellular differentiation[1][2][4][7].

Other names

COPR5C17orf79HSA272196TTP1cooperator of PRMT5Protein TTP1

Facilitation of PRMT5-dependent histone methylation (COPRS acts as an adaptor, recruiting PRMT5 to nucleosomes for specific methylation of histone H4 arginine 3[2])