COP9 signalosome complex subunit 1 (GPS1)

COP9 signalosome complex subunit 1 (GPS1) is a core component of the COP9 signalosome, a conserved multi-subunit protein complex involved in the regulation of protein degradation via the ubiquitin-proteasome system. It suppresses G-protein and mitogen-activated signal transduction in mammalian cells and participates in the deneddylation of cullin subunits of E3 ubiquitin ligase complexes, modulating their activity and affecting numerous cellular functions including cell cycle, DNA repair, and stress signaling. GPS1 also influences transcription factor stability (such as p53 and c-Jun) through its control over phosphorylation and ubiquitination states. Mutations or dysregulation of GPS1 are implicated in certain cancers and neurological conditions, highlighting its importance as a pivotal regulator of key signaling and proteostasis pathways[1][2][3]. **Notes on evidence:** - GPS1 is not considered a classic therapeutic target (like an enzyme or receptor), but rather a central regulator within a multi-protein complex[1][2]. - No approved drugs directly modulate GPS1 itself; structural/functional roles and risk of broad pleiotropy likely limit its tractability[1][2][3]. - It is essential in a range of physiological processes and can impact disease when mutated but is not presently linked to clinical biomarkers or drug mechanisms[1][2].

Other names

G protein pathway suppressor 1COPS1CSN1SGN1Signalosome subunit 1GPS-1JAB1-containing signalosome subunit 1Protein MFHCOP9 signalosome subunit 1