COP9 signalosome complex subunit 7B (COPS7B)

COP9 signalosome complex subunit 7B (COPS7B) is a protein-coding gene encoding a core component of the COP9 signalosome (CSN) complex, an evolutionarily conserved multiprotein complex that regulates the ubiquitin conjugation pathway in eukaryotes[1][5]. COPS7B contains a characteristic PCI (Proteasome, COP9 signalosome, eIF3) domain that is essential for the assembly and structural integrity of the complex[2]. The CSN complex, including COPS7B, functions primarily to catalyze the deneddylation (removal of the NEDD8 protein) of cullin subunits within cullin-RING E3 ubiquitin ligases, thereby regulating their ligase activity and downstream protein degradation processes[1][3]. CSN also participates in the phosphorylation and regulation of various substrates such as p53 and JUN, impacting cellular processes like cell cycle progression, signal transduction, DNA damage response, and developmental regulation[1][4]. Dysfunction or genetic variants of COPS7B have been linked to rare neurodegenerative and developmental disorders as well as cancer[1][3]. The signalosome, including COPS7B, is considered a therapeutic target for oncology and parasitology, though no approved drugs directly target this subunit at present. Disruption of COP9 signalosome activity is associated with significant cellular risks due to its central role in protein homeostasis[3].

Other names

COP9 signalosome subunit 7BCSN7BSGN7bSignalosome subunit 7bJAB1-containing signalosome subunit 7bCOP9 constitutive photomorphogenic homolog subunit 7B

Modulation of protein degradation via deneddylation and regulation of E3 ubiquitin ligase activity; potential inhibition of CSN activity leads to increased CRL ligase activity and cell death in cancer/preclinical models[3].