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Target intelligence / Profile preview
COP9 signalosome complex subunit 8 (COPS8)
- Target
- COPS8
- Molecular classification
- Other (component of multi-protein complex), not an enzyme, not a receptor, not a transporter, not an ion channel, not a transcription factor
01
Overview
COP9 signalosome complex subunit 8 (COPS8) is the smallest of eight protein subunits forming the highly conserved COP9 signalosome (CSN) complex, which is a key regulator in multiple cellular signaling pathways. The CSN complex is structurally and functionally related to the 19S regulatory particle of the 26S proteasome and plays a critical role in regulating ubiquitin ligase activity, particularly by deneddylating cullin proteins within SCF-type E3 ubiquitin ligase complexes. This regulation is essential for controlling protein turnover and modulating signaling cascades. Mutations or dysfunction in COPS8 have been linked to several genetic disorders and may also play roles in cancer pathogenesis through effects on proteostasis and cell cycle regulation[1][2][4][8].
- Other names
- COP9 signalosome subunit 8CSN8SGN8hCOP9MGC1297COP9 homologJAB1-containing signalosome subunit 8
02
Mechanism of action
Not applicable (no known direct-acting drugs)
03
Biological functions
Regulation of ubiquitin (Ubl) conjugation pathwayDeneddylation of cullin subunits of SCF-type E3 ubiquitin ligase complexesRegulation of various signaling pathwaysInvolvement in phosphorylation of proteins including p53/TP53, c-Jun/JUN, IκBα/NFKBIA, ITPK1, and IRF8/ICSBP
04
Disease associations
Cancer (through regulation of ubiquitin-proteasome system and cell cycle pathways)Smith-Magenis syndromeXeroderma pigmentosum, complementation group EPotentially other diseases involving defects in proteostasis
05
Safety considerations
Potential for broad effects on protein degradation and cell signaling if perturbedlikely essential for cell viability and function
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