Copine 1 (CPNE1) (CPNE1)

Copine 1 (CPNE1) is a calcium-dependent, phospholipid-binding protein that belongs to the evolutionarily conserved copine family [UniProt: Q99828]. It is characterized by two N-terminal C2 domains, which mediate membrane attachment in response to calcium, and a C-terminal von Willebrand factor A (vWA) domain that facilitates protein-protein interactions [PubMed: 28843033]. CPNE1 functions as a molecular scaffold, regulating key intracellular signaling pathways such as AKT/mTOR, NF-κB, and Raf/MEK/ERK, which are critical for cell survival, proliferation, and motility [PubMed: 31435355, PubMed: 30106434]. In the context of human pathology, CPNE1 is significantly upregulated in various cancers, including prostate, breast, and lung cancer, where it promotes tumor growth, epithelial-mesenchymal transition (EMT), and metastasis [PubMed: 29564511, PubMed: 33413433]. Consequently, CPNE1 mRNA and its encoded protein are being investigated as therapeutic targets and diagnostic biomarkers. Experimental strategies often employ RNA interference (RNAi) to deplete CPNE1 mRNA levels, thereby inhibiting oncogenic signaling and increasing the sensitivity of cancer cells to conventional treatments [PubMed: 32633325].

Other names

Copine ICPN1COPN1

Gene silencing via RNA interference (RNAi) targeting the CPNE1 transcript to prevent protein translation [PubMed: 32633325].