Copine-2 (CPNE2)

Copine-2 is a member of the copine family, a group of evolutionarily conserved calcium-dependent phospholipid-binding proteins found in eukaryotes. Copine-2 contains two N-terminal type II C2 domains responsible for calcium binding and membrane association, as well as a C-terminal von Willebrand factor type A (VWA) domain involved in protein–protein interactions[1][3][6]. Copine-2 can act as a calcium sensor, mediating the association of proteins with intracellular and plasma membranes in response to increased calcium levels[1][4][6]. While it is the product of the CPNE2 gene in humans, Copine-2’s best-characterized molecular roles involve calcium-dependent phospholipid interactions and membrane targeting. It is widely expressed, including in the brain, where copine family proteins play roles in neural function, synaptic activity, and potentially in neural diseases[1]. Currently, Copine-2 is not considered a classical therapeutic target (such as a receptor, enzyme, or transporter), and there are no known drugs directly interacting with it. Its involvement in disease is suggested by analogy to other copines but is not well established for Copine-2 itself.

Other names

Copine 2CPNE2Copine II