Copine-9 (CPNE9)

Copine-9 (CPNE9) is a member of the copine family, which are highly conserved, calcium-dependent, phospholipid-binding proteins. CPNE9 is predominantly expressed in the nervous system, including in retinal ganglion cells and neurons, and is implicated in calcium-mediated intracellular signaling and neurodevelopmental processes such as the regulation of dendritic and axonal morphology[2][3]. Structurally, CPNE9 contains two N-terminal C2 domains mediating calcium-dependent membrane association and a C-terminal von Willebrand A (vWA) domain involved in protein-protein interactions[2]. Unlike classical drug targets such as receptors or enzymes, CPNE9 currently has no known pharmacological ligands or drugs, nor is it classified as a direct therapeutic target[3]. Its precise molecular interactions and disease involvements are not fully characterized, though some disease associations (e.g., Joubert syndrome) have been reported in genetic studies[3]. Key points: - CPNE9 is not a receptor, enzyme, or transporter; its primary role is as a calcium sensor/scaffold protein involved in neuronal morphogenesis and signaling[2][3]. - No approved drugs or targeting agents currently act directly on Copine-9. - Copine-9 may serve as a marker of certain neuronal cell types or developmental stages but is not an established clinical biomarker. - There are no known specific safety concerns or adverse effects associated with modulation of CPNE9, largely because it is not currently a therapeutic target.

Other names

Copine family member 9CPNE9KIAA4217Copine IXcopine-9copine IXcopine family member IXcopine-like protein

Not applicable (no known targeted therapeutics)