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Copper Transporters (N/A)
- Target
- N/A
- Molecular classification
- Transporter, Membrane protein, P-type ATPase
01
Overview
Copper transporters are integral membrane proteins responsible for the uptake, distribution, and efflux of copper ions in human cells. Key proteins include CTR1 (SLC31A1), CTR2, ATP7A (Menkes protein), and ATP7B (Wilson disease protein). They ensure cellular and systemic homeostasis, and their dysfunction leads to various diseases.
- Other names
- CTR1 (Copper Transporter 1)SLC31A1CTR2 (Copper Transporter 2)ATP7A (Menkes protein)ATP7B (Wilson disease protein)
02
Mechanism of action
Modulation of copper transport affects drug uptake/efflux mechanisms.
03
Biological functions
Copper uptakeCopper distributionCopper effluxCopper homeostasisMetal transport
04
Disease associations
Menkes diseaseWilson diseaseNeurological degenerationCardiac hypertrophyVascular abnormalitiesImmune dysfunctionCancer
05
Safety considerations
Deficiency or mutation leads to diseases.Overload can result in tissue damage due to oxidative stress.
06
Interacting drugs
Cisplatin
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