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Core 1 O-glycan (None)

Target: None
Molecular classification: Glycan, O-linked Glycan

Overview

Core 1 O-glycans, also known as the T-antigen, are a fundamental subtype of mucin-type O-linked glycans. They consist of a galactose (Gal) molecule linked via a β1-3 bond to N-acetylgalactosamine (GalNAc), which is attached to serine or threonine residues on proteins. Core 1 O-glycans are involved in cell adhesion, immune responses, mucin formation, and protein folding. Aberrant expression is associated with diseases like cancer.

Other names: T-antigenGalβ1-3GalNAcα1-O-Ser/Thr

Mechanism of action

N/A

Biological functions

Cell-cell adhesionCell recognitionImmune response modulationMucin formationProtein foldingProtein stability

Disease associations

CancerInflammatory bowel disease

Biomarkers

Cancer biomarker (T-antigen)Sialyl-T antigen

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