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Target intelligence / Profile preview
Core 2 O-glycan variant of MUC5AC (Core 2 MUC5AC)
- Target
- Core 2 MUC5AC
- Molecular classification
- Glycoprotein, Mucin, O-linked glycan
01
Overview
The core 2 O-glycan variant of MUC5AC is a specific glycoform of the MUC5AC mucin protein, characterized by the presence of core 2-type O-linked glycans. This glycoform is often overexpressed or aberrantly presented in various cancers, particularly colorectal and pancreatic cancer, making it a valuable target for diagnostic and therapeutic strategies. Therapeutic antibodies like NEO-102 and PB223 specifically target this glycoform, mediating antibody-dependent cellular cytotoxicity (ADCC) against tumor cells expressing the core 2 O-glycan variant of MUC5AC.
- Other names
- Tumor-associated MUC5AC glycoformMUC5AC-C2MUC5AC with core 2 O-glycans
02
Mechanism of action
Antibody-dependent cellular cytotoxicity (ADCC)
03
Biological functions
Epithelial protectionLubricationBarrier functionCell adhesion (tumor-associated)Selectin binding (tumor-associated)
04
Disease associations
CancerColorectal cancerPancreatic cancerInflammation
05
Safety considerations
Potential for off-target effects in tissues with low-level MUC5AC expressionImmunogenicity of therapeutic antibodies
06
Interacting drugs
NEO-102 (NPC-1C)
1 more in the full profile.
07
Biomarkers
MUC5AC-C2 expression levels in tumor tissueSialyl-Lewis X/A (sLeX/A) expression on MUC5AC-C2
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