Corepressor interacting with RBPJ 1 (CIR)

Corepressor interacting with RBPJ 1 (CIR, CIR1) is a nuclear "transcriptional corepressor" that binds to the "CBF1/RBPJ" transcription factor, a key regulator in the Notch signaling pathway[1]. CIR interacts with histone deacetylase complexes, including HDAC2 and SAP30, linking RBPJ/CBF1 to chromatin modification machinery to mediate transcriptional repression of Notch target genes in the absence of activating signals. CIR is part of a corepressor complex that includes SMRT and SKIP, further modulating gene expression via chromatin remodeling. CIR shows broad expression in human tissues, particularly heart, skeletal muscle, and pancreas. While sometimes called the "corepressor of RBPJ and splicing regulator," there is no evidence that CIR functions as a splicing regulator; this appears to be an inaccurate or overly broad alias[1][2]. There is no evidence that CIR/CIRSR is used as a direct therapeutic target or that drugs are known to act on this protein. There are also no known roles as a biomarker or established safety concerns. Note: - The name "corepressor of RBPJ and splicing regulator" and the abbreviation "CIRSR" are not found in authoritative molecular or pharmacological databases. The accurate, widely accepted nomenclature is "Corepressor interacting with RBPJ 1" (CIR, CIR1). There may be confusion or error in secondary references about CIR having a splicing regulator function, so this target as described (CIRSR) is problematic for data standardization[1][2].

Other names

CIRCIR1CIRSRRecepinCBF1-interacting corepressorCBF1 interacting corepressorCBF1 (RBPJ) interacting corepressor 1corepressor of RBPJ and splicing regulatorrecepinTHE1B/CIR1