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CoREST Complex (None)

Target: None
Molecular classification: Protein Complex, Transcriptional Corepressor, Histone Modification, Enzyme Complex

Overview

The CoREST complex is a multi-protein transcriptional corepressor complex that plays a central role in the regulation of gene expression through chromatin modification. It is unique for containing both histone demethylase and deacetylase activities within the same assembly. Key components include RCOR1/2/3, LSD1/KDM1A, and HDAC1/2. It functions in transcriptional repression, particularly of neuron-specific genes, and is implicated in cancer and neurodevelopmental disorders.

Mechanism of action

Inhibition of histone demethylation (H3K4me/me2) and histone deacetylation (H3K9ac) to promote chromatin condensation and gene repression.

Biological functions

Transcriptional RepressionEpigenetic RegulationRegulation of gene expressionChromatin ModificationRegulation of DifferentiationRegulation of Development

Disease associations

CancerNeurodevelopmental Disorders

Safety considerations

Dysregulation can lead to aberrant cell fate determination and tumorigenesis.Inhibition may have pleiotropic effects due to broad regulatory role.

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