Target intelligence / Profile preview

Corn pollen protein (CPP)

Target
CPP
Molecular classification
Other (mixture of various classes; includes enzymes such as endoxylanase and beta-glucanase[1], structural proteins like expansins[2], calcium-binding allergens[3]), Allergen
01

Overview

Corn pollen protein refers collectively to the diverse set of proteins present within maize (Zea mays) pollen. This group includes several well-characterized allergens—notably those designated by names such as Zea m 1 (expansin B family), Zea m 13, among others—which can trigger IgE-mediated allergic responses in susceptible individuals due to cross-reactivity with other grass pollens[2][3][6]. The major functional classes represented include enzymes involved in cell wall modification during fertilization processes—such as endoxylanases and beta-glucanases that facilitate penetration through stigma tissues—and structural/modulatory molecules like expansins that loosen plant cell walls during germination/pollination events [1][2]. Additionally, some corn pollen-derived peptide hydrolysates have demonstrated antioxidant and antimicrobial activities with potential nutraceutical applications [7]. However, because "corn pollen protein" is an umbrella term covering many different molecules rather than one defined target or receptor, it should not be treated as a single canonical therapeutic target.

Other names
Maize pollen proteinMaize allergen proteinsZea mays pollen proteinsCPP
02

Biological functions

Cell wall modification/loosening during pollination and fertilization (e.g., expansins)[2]Enzymatic hydrolysis of plant cell wall components for tube entry/growth (e.g., xylanase, beta-glucanase)[1]Allergenic response induction in humans ("allergen")Antioxidant activity when hydrolyzed into peptidesAntimicrobial activity when hydrolyzed into peptides
03

Disease associations

Allergy/hypersensitivity reactions ("Other": respiratory allergy due to cross-reactive grass pollens)
04

Safety considerations

Allergenic potential leading to respiratory allergies/hay fever upon exposure/inhalation by sensitized individuals

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