Corneal endothelium protection

The corneal endothelium is a specialized monolayer of hexagonal cells lining the posterior cornea, maintaining tissue clarity by regulating stromal hydration through active ion transport ("pump-leak" mechanism). It is critical for vision and especially vulnerable during surgery, trauma, aging, and disease. Its poor regenerative ability means cell loss leads to progressive corneal edema and visual impairment; therapies focus on protection, minimizing apoptosis, and promoting repair through drugs like Rho kinase inhibitors, gene therapy, and surgical technique improvements[1][2][3][4][5][6][7][8].

Other names

corneal endothelial cellsCECsposterior corneal monolayer

Promotion of endothelial cell migration and repair (Rho kinase inhibitors); Anti-apoptotic action (Bcl-xL, p35); Mechanical protection from trauma during surgery (chopper shield technique)