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The corneal epithelial cell osmotic gradient refers to the difference in osmolarity (solute concentration) across the corneal epithelium, which drives water movement and is essential for maintaining corneal hydration, transparency, and overall ocular surface health. This gradient is dynamically regulated by ion transporters, aquaporins, and external factors such as tear film composition and evaporation. Disruption of this gradient is involved in dry eye disease and other ocular surface pathologies.
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