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Skin Corneocyte Adhesion (N/A)
- Target
- N/A
- Molecular classification
- Protein Complex, Cell Adhesion
01
Overview
Skin corneocyte adhesion refers to the mechanisms and molecular structures that maintain the cohesion of corneocytes, which are the terminally differentiated, flattened cells forming the outermost layer of skin—the stratum corneum. This adhesion is crucial for skin barrier integrity, resistance to mechanical stress, and protection against pathogens and water loss. The corneodesmosomes, composed of proteins like Desmoglein-1, Desmocollin-1, and Corneodesmosin, are key structural elements. Disruption can compromise barrier function, leading to skin disorders. Certain bacterial adhesins target components involved in human skin cell adhesion, such as Staphylococcus aureus using ClfB to bind ligands like loricrin and CDSN.
- Other names
- Stratum Corneum CohesionCorneocyte AdhesionEpidermal Barrier FunctionCorneodesmosome Function
02
Mechanism of action
N/A
03
Biological functions
Cell adhesionBarrier functionRegulation of desquamationWater retention
04
Disease associations
Atopic DermatitisInfection susceptibilityXerosis (Dry Skin)Other skin barrier dysfunction related conditions
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