Target intelligence / Profile preview

Corneodesmosin (CDSN)

Target: CDSN
Molecular classification: Glycoprotein, Adhesion protein

Overview

Corneodesmosin is a secreted glycoprotein located in the corneodesmosomal core and covalently linked to the cornified envelope of corneocytes. It is one of three adhesive proteins that compose corneodesmosomes, providing cohesive forces that connect adjacent corneocytes and maintain the integrity of the stratum corneum. Corneodesmosin demonstrates homophilic adhesive properties crucial for maintaining the structural integrity of the epidermis. Its proteolytic processing is essential for normal desquamation, and disruption of its function can lead to various skin disorders.

Biological functions

Cell adhesionMaintenance of epidermal barrierRegulation of desquamationReinforcing cell cohesion

Disease associations

Atopic dermatitisIchthyosisPsoriasisSkin barrier dysfunction

Safety considerations

Potential for abnormal desquamation or barrier function if disruptedRole in skin diseases characterized by abnormal desquamation or barrier function

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