Cornichon family AMPA receptor auxiliary protein 2 (CNIH2)

Cornichon family AMPA receptor auxiliary protein 2 (CNIH2) is a protein that acts as an auxiliary subunit for ionotropic glutamate receptors of the AMPA subtype[2][3][4]. It regulates the trafficking, membrane targeting, and gating properties of AMPA-selective glutamate receptors, promoting their localization to the cell surface and synapses, and thereby modulating excitatory neurotransmission in the central nervous system[7]. CNIH2 is classified as an auxiliary protein associated with ion channels, and although it is not the direct drug target (unlike the main AMPA receptor subunits), it plays an important modulatory role in glutamatergic neurotransmission and synaptic plasticity. Disease relevance is most likely in neurological and neuropsychiatric contexts, though there are no direct disease or drug associations confirmed in major genetic or protein databases at this time.

Other names

Protein cornichon homolog 2CNIH2CNILCNIH-2MGC50896CnilCornichon-like proteincornichon homolog 2

No drugs directly target CNIH2 according to current sources. Mechanistically, CNIH2 regulates AMPA receptor function, so drugs modulating AMPA receptors could be indirectly affected by CNIH2 status.