Cornichon family AMPA receptor auxiliary protein 4 pseudogene (CNIH4 (pseudogene))

Cornichon homolog 4 pseudogene is a **non-coding gene** derived from the cornichon family AMPA receptor auxiliary protein 4 (CNIH4). Unlike the protein-coding CNIH family members (CNIH1-4), the pseudogene does not produce a functional protein and is not a direct molecular target in therapeutic discovery. Protein-coding cornichon homologues, such as CNIH2 and CNIH3, act as auxiliary subunits for AMPA-type glutamate receptors and participate in the trafficking and maturation of these ion channels, but the pseudogene lacks established physiological or disease-related functions[3][4]. The related protein-coding gene, CNIH4, is involved in endoplasmic reticulum to Golgi vesicle-mediated transport and may influence GPCR trafficking[3]. However, the pseudogene ENSG00000220522 does not serve as an enzyme, receptor, transporter, or biomarker, nor does it interact with drugs or act as a safety concern. It may be referenced for genomic annotation and studies of gene evolution.

Other names

Cornichon homolog 4 pseudogeneLOC100287856cornichon family AMPA receptor auxiliary protein 4 pseudogeneCNIH4P