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Target intelligence / Profile preview
Coronary Vascular Smooth Muscle (CVSM)
- Target
- CVSM
- Molecular classification
- Smooth Muscle Cell, Cellular Component, Contractile Cell
01
Overview
Coronary vascular smooth muscle refers to the specialized smooth muscle cells located in the walls of coronary arteries. These cells are primarily responsible for regulating the diameter of coronary vessels, thereby controlling blood flow and pressure within the heart's own circulation. They play a critical role in maintaining adequate oxygen delivery to myocardial tissue under varying physiological demands. Dysregulation of these cells contributes to cardiovascular diseases like atherosclerosis, hypertension, and coronary artery spasm.
- Other names
- Coronary Artery Smooth Muscle CellsCoronary VSMCs
02
Mechanism of action
Regulation of vascular smooth muscle contraction and relaxation, modulation of intracellular signaling pathways, alteration of gene expression related to vascular tone and remodeling
03
Biological functions
Regulation of coronary blood flowVascular tone modulationVasoconstrictionVasodilationExtracellular matrix remodelingCell proliferationCell migrationContractionRelaxation
04
Disease associations
AtherosclerosisHypertensionCoronary Artery SpasmVariant AnginaPrinzmetal’s AnginaVascular RemodelingVascular CalcificationIschemic Heart Disease
05
Safety considerations
Excessive vasodilation leading to hypotensionParadoxical vasoconstrictionDrug interactions affecting vascular toneAdverse remodeling of coronary arteriesIncreased risk of atherosclerosis progression
06
Interacting drugs
Nitrates
5 more in the full profile.
07
Biomarkers
Endothelin-1 (ET-1)Nitric Oxide (NO) levelsAngiotensin IIL-type Calcium Channel expressionConnective Tissue Growth Factor (CTGF)Osteopontin
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