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Target intelligence / Profile preview
Coronavirus 3C-like protease (None)
- Target
- None
- Molecular classification
- Enzyme, Cysteine protease
01
Overview
The coronavirus 3C-like protease, also known as 3CLpro or main protease (Mpro), is a cysteine protease essential for the life cycle of coronaviruses. It cleaves viral polyproteins pp1a and pp1ab at conserved sites to release functional non-structural proteins (nsps) required for viral replication and transcription. Inhibitors targeting its active site block polyprotein processing and halt virus replication. Its high conservation across coronaviruses makes it a promising target for broad-spectrum antiviral drug development.
- Other names
- 3CLproMain ProteaseMproNonstructural Protein 5nsp5Chymotrypsin-like Cysteine Protease
02
Mechanism of action
Inhibition of viral polyprotein processing, thereby blocking viral replication.
03
Biological functions
ProteolysisViral replicationViral transcriptionPolyprotein processing
04
Disease associations
InfectionCOVID-19SARSMERS
05
Safety considerations
Potential for off-target effectsDrug resistance
06
Interacting drugs
Peptide-mimetic inhibitors
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