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Target intelligence / Profile preview
Coronavirus 3C-like Proteinase (None)
- Target
- None
- Molecular classification
- Enzyme, Cysteine protease
01
Overview
The coronavirus 3C-like proteinase (3CLpro), also known as main protease (Mpro) or nsp5, is a cysteine protease essential for the viral life cycle of coronaviruses. It cleaves viral polyproteins pp1a and pp1ab at eleven conserved sites, releasing nonstructural proteins necessary for replication and transcription. Its activity is indispensable for viral proliferation, making it an attractive target for antiviral drug development.
- Other names
- Main protease (Mpro)3CLpronsp5
02
Mechanism of action
Inhibition of viral polyprotein cleavage
03
Biological functions
Viral polyprotein processingViral replicationVirus maturation
04
Disease associations
InfectionCOVID-19SARSMERS
05
Safety considerations
Potential off-target effects in humans (though minimal due to limited human homologs)Drug resistance
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