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Target intelligence / Profile preview
Coronavirus Main Protease (Mpro)
- Target
- Mpro
- Molecular classification
- Enzyme, Protease, Cysteine hydrolase
01
Overview
The coronavirus main protease, also known as Mpro or 3C-like protease (3CLpro), is a highly conserved cysteine hydrolase found in all coronaviruses. It plays an indispensable role in viral replication by cleaving the large polyproteins pp1a and pp1ab at multiple specific sites to release functional nonstructural proteins essential for the formation of the viral replication/transcription complex. Inhibition of Mpro blocks viral replication by preventing proper processing of viral polyproteins.
- Other names
- 3C-like protease3CLpro
02
Mechanism of action
Inhibition of Mpro prevents viral polyprotein processing, blocking viral replication.
03
Biological functions
Viral replicationPolyprotein processingProtein maturation
04
Disease associations
Infection
05
Safety considerations
Potential for drug resistanceOff-target effects of inhibitors
06
Interacting drugs
Nirmatrelvir
1 more in the full profile.
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