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Target intelligence / Profile preview
Coronavirus spike glycoprotein (S protein)
- Target
- S protein
- Molecular classification
- Class I fusion protein, Transmembrane glycoprotein
01
Overview
The coronavirus spike glycoprotein is a large, trimeric class I fusion protein found on the surface of all coronaviruses. It mediates viral entry into host cells by binding to host cell receptors and facilitating fusion of viral and cellular membranes. It is the main target for neutralizing antibodies and the basis for most COVID-19 vaccines.
- Other names
- Spike proteinCoV_S1
02
Mechanism of action
Neutralizing antibodies bind to the spike protein, blocking receptor binding or membrane fusion.
03
Biological functions
Viral entryReceptor bindingMembrane fusionImmune response elicitation
04
Disease associations
Infection
05
Safety considerations
Potential for antibody-dependent enhancement (ADE)Risk of vaccine-induced immune thrombotic thrombocytopenia (VITT) with certain vaccine platforms.
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