Coronin-1A (CORO1A)

Coronin-1A (CORO1A) is an **actin-binding WD repeat protein** crucial for regulating the dynamics and organization of the **actin cytoskeleton** in immune cells, including T cells, neutrophils, macrophages, and natural killer cells[1][2][3]. Coronin-1A aids in processes like **phagocytosis**, immune cell migration, and the assembly and activation of the **NADPH oxidase complex**, notably by interacting with and modulating Arp2/3 complex and small GTPases like Rac, thereby facilitating efficient **reactive oxygen species (ROS)** production essential for pathogen clearance[2][3]. It plays a prominent role in regulating immune responses—deficiency in coronin-1A is linked to severe **immunodeficiency syndromes** in humans, characterized by defective T cell survival, impaired phagocyte function, and susceptibility to certain infections[1][2]. While it is not an established direct therapeutic drug target (e.g., no approved drugs acting on CORO1A), it is an important **biological regulator and biomarker** in immunology and cytoskeletal research.

Other names

Coronin 1ACORO1ACORO1Clipin-ATACOHCORO1p57coronin-1coronin-like protein Acoronin-like protein p57tryptophan aspartate-containing coat proteinClabp TACOCLABPCLIPINAIMD8actin binding protein 1ACRN4coronin-4