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Coronin-7 (CORO7)
- Target
- CORO7
- Molecular classification
- WD-repeat protein, F-actin regulator, Cytoskeletal regulator, Other (Golgi-associated protein)
01
Overview
Coronin-7 (CORO7) is a member of the coronin family of WD-repeat proteins, distinguished by containing two stretches of WD-40 repeats, in contrast to most other coronins which have one. Unlike conventional coronins which bind actin directly, Coronin-7 functions primarily as a regulator of F-actin organization and is essential for post-Golgi trafficking, maintenance of Golgi apparatus morphology, and anterograde transport from Golgi to endosomes. It localizes mainly to the trans-Golgi network and the cytoplasm. Its role is further modulated via post-translational modifications such as phosphorylation and ubiquitination. Mutations or deficiencies in Coronin-7 are associated with genetic disorders such as spondyloepimetaphyseal dysplasia, Strudwick type. Currently, there is no evidence supporting its use as a therapeutic target, biomarker, or as having known drug interactions based on available data.
- Other names
- Coronin-7CORO7Crn7POD1FLJ2202170 kDa WD repeat tumor rejection antigen homolog0610011B16RikCRN7
02
Biological functions
Regulation of F-actinGolgi to endosome transportMaintenance of Golgi apparatus morphologyVesicular traffickingOrganization of intracellular membrane compartments
03
Disease associations
Spondyloepimetaphyseal dysplasia, Strudwick typeOther (no broad implication in cancer, inflammation, or neurodegeneration shown in current sources)
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