Coronin-7–presequence translocase-associated motor 16 fusion protein (CORO7-PAM16)

CORO7-PAM16 refers to a naturally occurring *read-through fusion transcript* between the neighboring genes **CORO7 (Coronin-7)** and **PAM16 (presequence translocase-associated motor 16)** on chromosome 16. The fusion protein shares sequence identity with both parental proteins, but the biological and clinical significance of the read-through product itself is poorly defined. Individual components are involved in *Golgi/endosomal transport* (CORO7) and *mitochondrial protein import* (PAM16), but this fusion is not known to represent a validated receptor, enzyme, transporter, or a characterized therapeutic target[1][3][5][7][14]. The CORO7-PAM16 read-through gene has been associated with rare skeletal dysplasias but is not a standard drug target and has no known interacting drugs, mechanisms of action, biomarker, or reported safety concerns. **Additional notes:** - The entry is considered **incorrect as a standard therapeutic target**: CORO7-PAM16 is a gene fusion event with limited functional or pharmacological data and is primarily of genomic interest[1][3][7]. - If your goal is to extract canonical therapeutic targets, **CORO7-PAM16 should generally not be included**, whereas the individual entities *Coronin-7 (CORO7)* or *Presequence translocase-associated motor 16 (PAM16)* have well-defined identities and functional annotations[2][6][13]. **Summary:** CORO7-PAM16 is a read-through fusion protein arising from transcriptional read-through between CORO7 and PAM16, involved in rare developmental disorders, and is not a validated target for therapeutic intervention[1][3][5][7][14].

Other names

CORO7-PAM16 readthroughCORO7Coronin-7Crn7CORO7-PAM16 protein70 kDa WD repeat tumor rejection antigen homolog