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Correction of spherical aberration refers to various optical, surgical, and device-based strategies to reduce or neutralize spherical aberration—a type of optical distortion caused by the shape of the cornea or lens—thereby improving visual outcomes, particularly after cataract or refractive surgery. This is commonly accomplished using specialized intraocular lenses (IOLs), customized laser ablation patterns, or contact lenses engineered to counteract spherical aberration. Devices such as aspheric IOLs (e.g., Tecnis, Acrysof IQ, Sofport AO) are designed specifically to neutralize or optimize the level of ocular spherical aberration, resulting in improved contrast sensitivity and overall visual quality[1][2][3][4][5]. Spherical aberration correction is a *therapeutic approach* or engineering goal, not a discrete molecular entity or drug target.
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