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Target intelligence / Profile preview
Cortactin-binding protein 2 (CTTNBP2)
- Target
- CTTNBP2
- Molecular classification
- Other (cytoskeletal associated/scaffolding protein)
01
Overview
Cortactin-binding protein 2 (CTTNBP2) is a neuron-specific scaffolding protein characterized by six ankyrin repeats and multiple proline-rich domains[3][1]. It is predominantly expressed in the brain where it is highly concentrated in dendritic spines, regulating their formation and maintenance by directly interacting with cortactin – a key F-actin branching factor – and components of the phosphatase 2A (PP2A) complex[1][2][3]. CTTNBP2 organizes the actin cytoskeleton and microtubules, with functional modules mediating its respective interactions. It plays a critical role in neuronal morphogenesis; knockdown in neurons impairs dendritic spine density and arborization[1][2]. Variations in the CTTNBP2 gene are associated with autism spectrum disorder, suggesting a significant role in neural development and synaptic signaling[2]. CTTNBP2 is not known as a direct therapeutic drug target, nor are there known small-molecule modulators or biomarker applications at present[1][2][3].
- Other names
- CTTNBP2CortBP2CBP90C7orf8Orf4cortactin binding protein 2
02
Biological functions
Regulation of dendritic spine formationMaintenance of dendritic spinesRegulation of dendritic arborizationMicrotubule stabilization and bundlingF-actin cytoskeletal organizationSynaptic targeting/regulation of protein phosphatase 2A complex
03
Disease associations
Neurodevelopmental disorders (notably autism spectrum disorder)Other (supportive evidence for neural development and function)
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