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Corticosteroid 11-beta-dehydrogenase isozyme 1 (11β-HSD1)
- Target
- 11β-HSD1
- Molecular classification
- Enzyme, Short-chain dehydrogenases/reductases
01
Overview
Corticosteroid 11-beta-dehydrogenase isozyme 1 (11β-HSD1) is an NADPH-dependent enzyme that catalyzes the reversible conversion of inactive cortisone to active cortisol. It is highly expressed in metabolic tissues including the liver, adipose tissue, and central nervous system. By regenerating active cortisol within tissues, it amplifies local glucocorticoid action independently of circulating hormone levels. Overactivity or dysregulation has been implicated in obesity-related complications and cognitive symptoms linked with stress axis overactivation.
- Other names
- HSD11B1CORTRD2HDLSDR26C1
02
Mechanism of action
Inhibition of cortisone to cortisol conversion
03
Biological functions
Glucocorticoid activation/recyclingCortisone to Cortisol conversionRegulation of glucose metabolismModulation of immune responsesOxysterol metabolism
04
Disease associations
Metabolic syndromeObesity-related complicationsCognitive symptoms linked with stress axis overactivationInflammation
05
Safety considerations
Potential for metabolic side effectsInfluence on stress axisEffects on cognitive function
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