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Corticosteroid-binding globulin (None)

Target: None
Molecular classification: Serpin superfamily (clade A), Glycoprotein, Non-inhibitory serpin

Overview

Corticosteroid-binding globulin (CBG), also known as transcortin, is a glycosylated plasma protein primarily responsible for transporting glucocorticoids (such as cortisol) and progesterone in the blood. It plays a crucial role in modulating the tissue availability of these steroid hormones by acting as their main carrier in circulation.

Other names: Transcortin

Mechanism of action

Conformational change upon RCL cleavage leading to reduced steroid binding affinity and release.

Biological functions

Glucocorticoid transportProgesterone transportRegulation of glucocorticoid bioavailabilitySteroid reservoirModulation of glucose metabolismRegulation of stress responseInflammation modulationNeurocognitive function regulation

Disease associations

InflammationChronic musculoskeletal pain/fatigue disordersFertility issues

Biomarkers

Free cortisol levelsCBG levels (for inflammation assessment)

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