Corticosteroid Hormone Receptor (CHR)

Corticosteroid hormone receptors are a class of intracellular receptors that bind corticosteroids, including glucocorticoids and mineralocorticoids. They are members of the nuclear hormone receptor superfamily and function as ligand-activated transcription factors, regulating gene expression in response to steroid hormones. The main subtypes are the glucocorticoid receptor (GR) and the mineralocorticoid receptor (MR). Activation leads to diverse physiological processes, including metabolic control, immune modulation, and stress adaptation.

Other names

Glucocorticoid ReceptorMineralocorticoid ReceptorGRMRNuclear Receptor Subfamily 3, Group CNR3C

Ligand binding induces receptor dimerization, nuclear translocation, DNA binding to hormone response elements, and modulation of gene transcription via recruitment of coactivators or corepressors.