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Target intelligence / Profile preview
Corticotrophin-releasing factor receptor 1 (CRHR1)
- Target
- CRHR1
- Molecular classification
- G-protein coupled receptor, Receptor
01
Overview
Corticotrophin-releasing factor receptor 1 (CRHR1) is a G-protein coupled receptor that binds neuropeptides from the corticotropin-releasing hormone family, primarily corticotropin-releasing hormone (CRH) and urocortin (UCN). It plays a central role in coordinating endocrine, autonomic, and behavioral responses to stress via the hypothalamic-pituitary-adrenal axis (HPA axis). Dysregulation has been implicated as a potential target for treatment of depression and anxiety disorders due to its central role in stress response modulation.
- Other names
- CRF1Corticotropin-releasing hormone receptor 1
02
Mechanism of action
Agonist; Antagonist; Modulation of adenylyl cyclase signaling pathway
03
Biological functions
Signal transductionStress response coordinationEndocrine regulationAutonomic regulationBehavioral regulationRegulation of digestionRegulation of immune responseMood/emotion regulationRegulation of sexualityRegulation of energy storage/consumption
04
Disease associations
DepressionAnxiety disorders
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