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Target intelligence / Profile preview
Corticotropin-Releasing Factor (CRF)
- Target
- CRF
- Molecular classification
- Peptide hormone, Neuropeptide
01
Overview
Corticotropin-releasing factor (CRF), also known as corticotropin-releasing hormone (CRH) or corticoliberin, is a 41-amino acid peptide hormone and neuropeptide that plays a central role in the body’s response to stress. It is primarily produced in the paraventricular nucleus of the hypothalamus and acts as the main driver of the hypothalamic–pituitary–adrenal (HPA) axis. Dysregulation of CRF is implicated in various psychiatric disorders and other conditions. CRF exerts its effects through two main receptor types: CRHR1 and CRHR2.
- Other names
- Corticotropin-Releasing HormoneCRHCorticoliberin
02
Mechanism of action
CRF antagonists block CRF receptors (CRHR1 and CRHR2), inhibiting the downstream effects of CRF on the HPA axis and other physiological processes.
03
Biological functions
Stress responseHPA axis activationAppetite suppressionAnxiety regulationMemory modulationAutonomic function regulationImmune function modulationGastrointestinal motility regulationCardiovascular function regulation
04
Disease associations
DepressionAlzheimer's diseaseStress disordersChronic pain syndromes
05
Safety considerations
Potential for endocrine disruptionCardiovascular effects
06
Interacting drugs
CRHR1 antagonists
1 more in the full profile.
07
Biomarkers
CRF levels in cerebrospinal fluidACTH levelsCortisol levels
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