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Target intelligence / Profile preview
Corticotropin-releasing factor 2 receptor (CRHR2)
- Target
- CRHR2
- Molecular classification
- G protein-coupled receptor, GPCR, Type 2 GPCR
01
Overview
The corticotropin-releasing factor 2 receptor (CRHR2) is a type 2 G protein-coupled receptor activated by urocortins II & III and corticotropin-releasing hormone. It plays a crucial role in stress adaptation, cardiovascular regulation, angiogenesis, and metabolic processes. Dysregulation of CRHR2 is implicated in various conditions including anxiety, PTSD, heart failure, and cancer, making it a potential therapeutic target.
- Other names
- CRF-RBCRF2CRFR2HM-CRF
02
Mechanism of action
Activation of adenylate cyclase via Gαs, leading to increased intracellular cAMP
03
Biological functions
Stress adaptation/recoveryRegulation of hypothalamic-pituitary-adrenal axisSerotonergic activity modulationInhibition of angiogenesisRegulation of feeding behaviorRegulation of lipid metabolismSignal transduction
04
Disease associations
Anxiety disordersPost-traumatic stress disorder (PTSD)Chronic pain/fatigue syndromesHeart failureCardiac hypertrophyCancerIschemic cardiovascular diseases
05
Safety considerations
Chronic activation can promote anxiety-like statesChronic activation can lead to maladaptive cardiac remodeling and dysfunction
06
Biomarkers
Urocortin II levels in heart failure patients
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