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Target intelligence / Profile preview
Corticotropin-Releasing Hormone Receptor (CRHR)
- Target
- CRHR
- Molecular classification
- G protein-coupled receptor, GPCR
01
Overview
Corticotropin-releasing hormone receptors (CRHRs) are integral membrane proteins that mediate the effects of corticotropin-releasing hormone (CRH), a key neuropeptide involved in the stress response. There are two main subtypes: CRHR1 and CRHR2. Both belong to the G protein-coupled receptor (GPCR) superfamily and play central roles in regulating the hypothalamic-pituitary-adrenal (HPA) axis, which governs endocrine, behavioral, autonomic, and immune responses to stress.
- Other names
- CRF ReceptorCRH ReceptorCorticotropin Releasing Factor Receptor
02
Mechanism of action
Ligand binding induces conformational change in the receptor. Typically couples with Gαs proteins → activates adenylyl cyclase → increases cyclic AMP (cAMP). cAMP activates protein kinase A (PKA), leading to phosphorylation events that alter gene expression, hormonal secretion, metabolism.
03
Biological functions
Stress response regulationHPA axis activationModulation of behaviorModulation of metabolismModulation of reproductionSignal transduction
04
Disease associations
Major depressive disorderAnxiety disordersAlzheimer's diseaseMetabolic disturbances
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