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Target intelligence / Profile preview
Corticotropin-Releasing Factor Receptor 2 (CRF2)
- Target
- CRF2
- Molecular classification
- G protein-coupled receptor, Receptor
01
Overview
Corticotropin-Releasing Factor Receptor 2 (CRF2) is a G protein-coupled receptor that modulates stress responses both centrally and peripherally. It is activated by urocortins and corticotropin-releasing hormone (CRH), leading to downstream signaling events. It is expressed in various tissues, including the brain, heart, skeletal muscle, and gastrointestinal tract, and plays a role in cardiovascular function, gastric motility, and stress adaptation. Selective antagonists like astressin-II B and antisauvagine–30 are useful tools for research and potential therapeutics.
- Other names
- CRHR2
02
Mechanism of action
Activation of G proteins (primarily Gs), leading to adenylate cyclase activation and downstream signaling events.
03
Biological functions
Signal transductionStress response modulationCardiovascular regulationRegulation of gastric motilityIntegration of endocrine, behavioral, autonomic, and immune responses
04
Disease associations
Stress-related disordersCardiovascular diseasesSubstance use behaviors
05
Interacting drugs
Urocortin II
4 more in the full profile.
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