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Target intelligence / Profile preview
Corticotropin-Releasing Factor Receptor Type 2 (CRFR2)
- Target
- CRFR2
- Molecular classification
- G protein-coupled receptor, GPCR
01
Overview
Corticotropin-Releasing Factor Receptor Type 2 (CRFR2) is a G protein-coupled receptor that mediates the effects of corticotropin-releasing factor (CRF) and related peptides like Urocortin II and Urocortin III. It plays a crucial role in regulating stress responses, HPA axis function, serotonergic activity, angiogenesis, energy homeostasis, and thermoregulation. The receptor exhibits splice variants with distinct tissue distributions, impacting its diverse physiological functions and potential therapeutic applications in psychiatric, cardiovascular, and metabolic disorders.
- Other names
- CRHR2CRF-RBCRF2HM-CRFcorticotropin releasing hormone receptor 2
02
Mechanism of action
Agonists (Urocortin II, Urocortin III, Corticotropin-releasing hormone) activate the receptor, leading to downstream signaling cascades. Antagonists inhibit receptor activation.
03
Biological functions
Stress responseHPA axis regulationModulation of serotonergic activityAngiogenesis regulationEnergy homeostasisThermoregulation
04
Disease associations
Psychiatric disordersAnxietyDepressionCardiovascular diseaseMetabolic diseasesCancer
05
Safety considerations
Potential for off-target effects due to structural similarity with other GPCRsComplex role in stress response may lead to unpredictable effects on anxiety and mood
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