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Target intelligence / Profile preview
Corticotropin-Releasing Hormone Receptor 1 (CRHR1)
- Target
- CRHR1
- Molecular classification
- G protein-coupled receptor
01
Overview
Corticotropin-Releasing Hormone Receptor 1 (CRHR1) is a G-protein coupled receptor that binds corticotropin-releasing hormone (CRH) and related neuropeptides such as urocortins. It is a major regulator of the hypothalamic-pituitary-adrenal (HPA) axis, which controls stress responses by modulating endocrine, autonomic, behavioral, and immune functions. Dysregulation or genetic variation at this locus has been implicated in mood disorders such as depression and anxiety.
- Other names
- CRF1Corticotropin-releasing factor receptor 1
02
Mechanism of action
Antagonism of CRHR1 reduces HPA axis activity and stress responses.
03
Biological functions
Stress response coordination via HPA axisNeural developmentSignal transductionRegulation of endocrine, autonomic, behavioral, and immune functions
04
Disease associations
Mood disordersDepressionAnxiety
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