Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Corticotropin-releasing hormone receptor 2 (CRHR2)
- Target
- CRHR2
- Molecular classification
- G protein-coupled receptor, GPCR, Receptor
01
Overview
Corticotropin-releasing hormone receptor 2 (CRHR2) is a G protein-coupled receptor that mediates the physiological response to stress by binding corticotropin-releasing hormone (CRH) and related peptides like urocortins. It plays a key role in modulating stress responses, regulating neuroendocrine integration, and controlling feeding behavior and circadian rhythms. Dysregulation of CRHR2 is associated with various conditions including anxiety disorders, cardiovascular diseases, and gastrointestinal disorders. Antagonists targeting this receptor are being explored for therapeutic use.
- Other names
- CRF-RBCRF2CRFR2HM-CRF
02
Mechanism of action
Antagonism of CRHR2, leading to modulation of stress response and downstream signaling pathways.
03
Biological functions
Stress response modulationNeuroendocrine integrationFeeding behavior regulationCircadian rhythm regulationSignal transduction
04
Disease associations
Anxiety disordersStress-related psychiatric conditionsCardiovascular diseasesChronic heart failureGastrointestinal disordersIrritable bowel syndromeIschemia/reperfusion-induced enteritisCancer
05
Safety considerations
Potential for anxiety-like behaviors with deficiency or dysfunctionCardiovascular abnormalitiesAltered metabolism/feeding patterns
Beyond the preview
Go deeper on Corticotropin-releasing hormone receptor 2 (CRHR2).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Corticotropin-releasing hormone receptor 2 (CRHR2).