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Corynebacterium diphtheriae Exotoxin

Molecular classification: Exotoxin, Enzyme, ADP-ribosyltransferase

Overview

Diphtheria toxin is a protein exotoxin secreted by *Corynebacterium diphtheriae*. It is an A-B toxin that binds to HBEGFR on host cells and enters the cytoplasm via endocytosis. The A subunit catalyzes ADP-ribosylation of elongation factor 2 (EF-2), inhibiting protein synthesis and leading to cell death. It is responsible for the primary symptoms of diphtheria.

Other names: Diphtheria toxintox

Mechanism of action

ADP-ribosylation of elongation factor 2 (EF-2), leading to inhibition of protein synthesis.

Biological functions

Inhibition of protein synthesisCell death inductionADP-ribosylation of EF-2

Disease associations

DiphtheriaMyocarditisNeuropathy

Safety considerations

Systemic toxicityMyocarditisNeuropathyLocal tissue destruction

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