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Corynebacterium diphtheriae Toxin Receptor Binding Domain
- Molecular classification
- Protein domain, Toxin, Receptor ligand
01
Overview
The receptor binding domain of the diphtheria toxin, located within Fragment B (residues ~194-535), is responsible for specifically recognizing and binding to heparin-binding EGF-like growth factor precursor (HB-EGF) on the surface of human cells. This interaction is essential for the toxin's entry into the cell and subsequent cytotoxicity.
- Other names
- Diphtheria toxin receptor binding domainFragment B receptor binding domainDtxR binding domain
02
Mechanism of action
Binds to HB-EGF, facilitating endocytosis and toxin entry into cells
03
Biological functions
Receptor bindingCell entryToxin deliveryHost cell recognition
04
Disease associations
DiphtheriaInfection
05
Safety considerations
ToxicityOff-target effects when used in targeted therapiesImmunogenicity
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