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Cough center in medulla

Molecular classification: Neural circuit, Respiratory control center

Overview

The cough center is a functional region within the medulla oblongata that coordinates the cough reflex. It integrates sensory input from airway irritant receptors and generates a motor pattern for forceful expulsion of air to clear the airways. The center overlaps with respiratory rhythm generator networks and is modulated by higher brain centers.

Mechanism of action

Inhibition of neuronal activity within the cough center

Biological functions

Coordination of cough reflexAirway protectionRespiratory control

Disease associations

CoughRespiratory disordersAirway clearance dysfunction

Safety considerations

Impaired airway protection with excessive inhibitionSide effects of centrally acting antitussives

Interacting drugs

Antitussives (centrally acting)

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