Nuclear receptor subfamily 2 group F member 2 (NR2F2)

NR2F2 (Nuclear receptor subfamily 2 group F member 2), also known as COUP transcription factor 2 (COUP-TFII), is an orphan nuclear receptor and transcription factor encoded by the *NR2F2* gene in humans[1]. It plays a central role in embryogenesis, organ development, and adult tissue homeostasis, particularly by regulating cell fate decisions, differentiation, and vascular identity[2][3]. NR2F2 influences gene expression both positively and negatively depending on cell type and promoter context, interacts with various signaling pathways (Notch, VEGF, Wnt/β-catenin), and partners with other nuclear receptors such as RXR and HNF-4[2]. Although lacking a physiological ligand, it can be modulated by high concentrations of retinoic acid and synthetic naphthol compounds, which affect its activity through structural changes in the ligand-binding domain[1][2]. Dysregulation of NR2F2 is implicated in multiple diseases, including birth defects (congenital heart defects, gonadal dysgenesis), metabolic syndromes, and cancer, where its role is context-dependent[2][3]. Due to its integral regulatory function across various biological processes, NR2F2 is a candidate therapeutic target under investigation, though no approved drugs currently exist that selectively modulate its activity[2][3].

Other names

COUP transcription factor 2COUP-TFIIARP-1TFCOUP2COUPTFBSVP40NF-E3COUPTF2Apolipoprotein A-I regulatory protein 1ARP1CHTD4SRXX5chicken ovalbumin upstream promoter transcription factor 2COUP transcription factor IIADP-ribosylation factor related protein 1

Ligand-induced conformational changes (retinoic acid, naphthol family compounds). Modulation of gene expression by binding DNA response elements. Protein–protein interactions affecting transcription of other nuclear hormone receptors (e.g., PPAR, VDR, TR, RAR). Recruitment of co-activators and co-repressors.