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Target intelligence / Profile preview
COVID-19 3C-like Protease (3CLpro)
- Target
- 3CLpro
- Molecular classification
- Enzyme, Protease, Cysteine protease
01
Overview
The COVID-19 3C-like protease (3CLpro), also known as the main protease (Mpro) or nonstructural protein 5 (nsp5), is a cysteine protease essential for SARS-CoV-2 replication. It cleaves viral polyproteins pp1a and pp1ab at eleven conserved sites, releasing nonstructural proteins (nsps) required for forming the replication-transcription complex. Inhibition of 3CLpro blocks viral polyprotein processing, halting virus replication, making it a key target for antiviral drug development.
- Other names
- Main ProteaseMproNonstructural Protein 5nsp5Chymotrypsin-like Protease
02
Mechanism of action
Inhibition of viral polyprotein processing, halting virus replication.
03
Biological functions
Viral replicationPolyprotein processingProteolysis
04
Disease associations
InfectionCOVID-19
05
Interacting drugs
Covalent inhibitors
2 more in the full profile.
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