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Target intelligence / Profile preview
Coxsackievirus A16 (CA16)
- Target
- CA16
- Molecular classification
- Virus, Picornaviridae, Enterovirus, ssRNA virus
01
Overview
Coxsackievirus A16 (CA16) is a non-enveloped, positive-sense single-stranded RNA virus belonging to the species *Human enterovirus A*. It is a primary causative agent of hand, foot, and mouth disease (HFMD), especially in infants and young children. CA16 utilizes SCARB2 for uncoating and heparan sulfate glycosaminoglycans for attachment to host cells. While most infections are mild, severe complications can occur. There are currently no specific antivirals approved; management remains supportive.
- Other names
- CVA16Coxsackievirus A type 16Human enterovirus A16
02
Biological functions
Viral replicationInfectionHost cell entryGenome translationCapsid assembly
03
Disease associations
Hand, foot, and mouth disease (HFMD)Aseptic meningitis (rare)Encephalitis (rare)Myocarditis (rare)Pneumonia (rare)
04
Safety considerations
Potential for severe complications (neurological, cardiac, respiratory) in rare casesAntigenic variability and genetic recombination leading to altered virulenceLack of specific antiviral treatments
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