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Target intelligence / Profile preview
Coxsackievirus and Adenovirus Receptor (CAR)
- Target
- CAR
- Molecular classification
- Type I transmembrane protein, Cell adhesion molecule, Receptor, Immunoglobulin superfamily member
01
Overview
The Coxsackievirus and adenovirus receptor (CAR) is a transmembrane protein that serves as a primary cellular entry point for group B coxsackieviruses and subgroup C adenoviruses in humans. Beyond its role in viral infection, CAR functions as a cell adhesion molecule, participating in homophilic interactions to stabilize cell-cell contacts, especially at tight junctions in epithelial tissues. It is highly expressed in epithelial cells and cardiac muscle, influencing various biological processes and disease pathologies, including myocarditis and asthma.
- Other names
- CXADR
02
Biological functions
Viral receptorCell adhesionTight junction stabilizationModulation of cell-cell contact
03
Disease associations
MyocarditisDilated cardiomyopathyArrhythmiasAsthmaInflammatory airway diseasesViral infections
04
Safety considerations
Facilitation of viral entry into cellsPotential role in inflammatory responses
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