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Target intelligence / Profile preview
Coxsackievirus B (CVB)
- Target
- CVB
- Molecular classification
- Virus, Picornaviridae, Enterovirus
01
Overview
Coxsackievirus B (CVB) is a group of six serotypes (CVB1–CVB6) of enteroviruses within the Picornaviridae family. These are small, non-enveloped, positive-sense single-stranded RNA viruses. CVBs are pathogenic and can cause a wide range of diseases in humans, from mild febrile illnesses to severe conditions such as myocarditis and aseptic meningitis. Transmission is mainly fecal-oral, but also occurs via oral-oral routes and respiratory droplets. Disease severity depends on age, immune status and other factors. CAR and DAF/CD55 function as entry receptors.
- Other names
- Coxsackievirus B1Coxsackievirus B2Coxsackievirus B3Coxsackievirus B4Coxsackievirus B5Coxsackievirus B6Enterovirus B
02
Biological functions
Viral replicationCellular infectionInduction of host immune responseCytolysis
03
Disease associations
MyocarditisPericarditisAseptic MeningitisPleurodyniaEncephalitisGastrointestinal illnessNeonatal systemic illnessMyalgic encephalomyelitis/Chronic Fatigue SyndromeType 1 diabetes (potential link)
04
Safety considerations
Potential for severe complications in infants and immunocompromised individualsPossible link to chronic diseasesPotential for rapid progression to severe disease (e.g., myocarditis leading to heart failure)
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