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Target intelligence / Profile preview
CR1 antisense RNA 1 (CR1-AS1)
- Target
- CR1-AS1
- Molecular classification
- Long non-coding RNA, Antisense RNA, Other
01
Overview
CR1 antisense RNA 1 (CR1-AS1), also known as AL137789.1, is a long non-coding RNA transcribed in the antisense orientation to the CR1 gene. As an antisense RNA, it does not code for a protein but may regulate the expression of sense genes through various mechanisms. Recent studies indicate CR1-AS1 can promote tumor progression and immune evasion in pancreatic cancer, implying a regulatory role in tumor biology[5]. Like other antisense lncRNAs, it may act via transcriptional interference, mRNA stability modulation, or chromatin remodeling. There is growing evidence that CR1-AS1 is part of a broader class of antisense RNAs with regulatory and disease-related properties[5][8]. There are currently no known drugs targeting this RNA, and it is not classified as a canonical drug target such as a receptor or enzyme.
- Other names
- AL137789.1
02
Biological functions
Regulation of gene expressionTumor progressionImmune escape
03
Disease associations
Cancer (evidence in pancreatic cancer)possibly other cancers
04
Biomarkers
Potential biomarker for cancer progression
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